A case control study on comparing the risk of mortality between pediatric down syndrome patients with and without cardiac anomalies in a tertiary healthcare center.
Down syndrome (DS) is a set of cognitive and physical symptoms that result from having an extra chromosome 21 or an extra piece of that chromosome, approximately 1:600 newborns are affected by DS, and an incidence in Saudi Arabia of 1 in 554 live births.
The aim of our study is to assess the different health outcomes between pediatric DS patients with and without cardiac anomalies, and to identify significant predictors of mortality in Down syndrome patient’s with/without cardiac anomaly.
258 DS patient aged from 0-16 years old were collected from KAMC heart center, patient data such as, congenital heart disease, surgical repair of the cardiac anomaly, and information concerning the hospital and Intensive care unit length of stay and other comorbidities were obtained using data collection sheet,
85.6% are alive, and 83.3% has cardiac anomaly, the most common anomaly in our sample AVSD (38.8%), Kaplan Meier survival curve showed a significant difference in mortality rate between DS patient who had surgical repair of the heart anomaly in comparison to the DS patient who did not have surgical correction of the heart anomaly, however, survival of DS patients with or without cardiac anomaly were not statistically significant, the identified survival predictors were surgical repair of the cardiac anomaly, number of ICU admissions, pulmonary hypertension, and presence of recurrent infections, In a stepwise cox regression, ICU (p=0.001), Pulmonary hypertension (p=0.01), infection (p=0.02) and unrepaired of the cardiac anomaly (p<0.0001) were the variables independently associated with hazard of death.
|Required role||Manuscript writing|
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